Questions and Answers
Dear Sir:
I take 5 mg per day of Hytrin for BPH, not high blood pressure. At
previous times I have taken 10 mg, but prefer keeping to the lower level.
I would like to understand more about the relationship between Hytrin and levels of serotonin. Specifically, are there any studies which indicate that Hytrin causes a reduction in serotonin levels?
I have been treated for mild
depression in the past with the best result (and fewest side effects) from
Remeron. In looking at my history, I've realized that the onset of the
depression coincided somewhat with the use of Hytrin for BPH. Are you aware
of any pharmacological support for this notion?
Thank you.
Hi Jim ...
No, Hytrin ( terazosin) at clinically used doses is a rather
specific blocker of peripheral alpha1 adrenoreceptors. At higher
concentrations it directly dilates small blood vessels, but this has nothing
to do with serotonin. It has no central effects other than those caused by
drop in blood pressuse with initial doses.
Certainly no evdence of interference with normal levels of serotonin.
Best wishes.